Scientist, In Vivo Physiology
📋 Role Overview & Responsibilities
Company info
NewLimit is a biotechnology company working to radically extend human healthspan. We’re developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale.
Description
NewLimit is seeking an scientist with in vivo physiology experience to contribute to our Metabolism and Immunology programs. Our therapeutic programs are developing reprogramming medicines to restore youthful function in old cells, treating otherwise intractable conditions. In this role, you will design and implement state-of-the-art in vivo models to facilitate the development of these reprogramming medicines, contribute to Discovery and pre-clinical decision making, and serve as a subject matter expert.
As a Scientist On Our Team, You Will
Collaborate with our Metabolism and Immunology teams to design, build, and employ in vivo models to support therapeutic developmentEngineer humanized liver models for reprogramming therapeutics discovery screensEvaluate reprogramming therapeutic candidates using in vivo functional assays to select therapeutic candidatesDevelop methods for in vivo delivery of nucleic acid payloads in collaboration with our Epigenetic Editing teamAnalyze and interpret experimental data to drive pre-clinical decision making
Requirements
B.S. and 3+ years of work experience or Ph.D. in cell biology, molecular biology, physiology, or a related field or equivalent work experience. Experience with in vivo surgical and dosing procedures in rodent models (mouse or rat)Experience managing an in vivo model breeding programExperience with cell and tissue isolation from in vivo modelsExperience with histology or immunohistochemistry preparation
Nice to have
History of contributing to a drug development program at the pre-clinical or clinical development stageExperience working with liver disease models and associated proceduresExperience working with immunocompromised humanized mouse modelsExperience with in vivo nucleic acid delivery (hydrodynamic, viral vectors, lipid nanoparticles
Frequently Asked Questions
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This position is located in South San Francisco, CA with potential relocation and sponsorship assistance depending on candidate qualifications.
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