Analytical Development Scientist

CONTRACT

MUST HAVES:PhD in Analytical Chemistry, Biophysics, or related fields with experience in Analytical Development for biologics or gene therapy products5+ years of research work (can include academic experience)Hands on experience with mass photometry, SEC-MALS, and/or HPLC to characterize AAV particles

Position SummarySeeking an analytical chemistry scientist with a collaborative andinnovative mindset to join our Analytical Development group in Woburn, MA. Strong preference will be given to a candidate with proven experience in developing biophysical and analytical chemistry assays like SEC-MALS, HPLCs, CE-SDS, iCIEF as it relates to biologics and gene therapy products. Reporting to the Associate Director of Analytical Development, the Scientist will be responsible for the development of biophysical and analytical chemistry methods to further gene therapy products throughout clinical development, as well as performing BLA-enabling characterization studies. In this role you are encouraged to interact and collaborate across other functions

Responsibilities• Investigate and evaluate cutting edge biophysical and analyticalinstrumentation for AAV, AAV-Ab characterization.• Develop methods to quantitatively measure the purity and heterogeneityof AAV gene therapy vectors, including empty capsid, aggregation, and capsidprotein purity.• Evaluate and implement new analytical platforms, such as MassPhotometry, SEC-MALS, and HPLC, to characterize AAV particles.• Provide technical support to cross-function groups and externalcollaborators.• Effectively collaborate with internal analytical development teams andmanage the transfer of analytical methods to business partners. Provide guidanceand foster effective communications during the tech transfer.• Write, prepare, and present technical data, technical reports, and standardoperating procedures (SOPs) for internal use and transfer to external sites.

Qualifications• PhD in Analytical Chemistry, Biophysics, or related fields with experiencein Analytical Development for biologics or gene therapy products.• Demonstrated ability to bring efficiency and innovations into analyticaltesting and operation.• Demonstrated ability to build and maintain positive and collaborativerelationships with management, peers, subordinates, and externally with businesspartners.• Hand-on experienced with SEC-MALS, HPLC, CE, DLS, and moreinstruments are desired.• Knowledge of analytic methods for quantification and characterization ofAAV vectors and Protein is desired.• Strong, demonstrated ability to work independently, maintain a high levelof productivity, focus on priorities, and thrive in a fast-paced biopharmaceuticalenvironment.• Ideal candidate must be team focused and demonstrate high level ofintegrity.