Director Non Clinical R&D
📋 Role Overview & Responsibilities
Director of Non-Clinical R&DSan Francisco, CA
Our client is a pioneering biotech startup based in San Francisco, CA, dedicated to revolutionizing genetic medicine through innovative Lipid Nanoparticle (LNP) technology. Led by a visionary PhD graduate from Stanford University, we are committed to advancing healthcare through groundbreaking biotechnology solutions. Our proprietary delivery mechanism offers unparalleled efficacy and safety, setting a new standard in RNA/DNA therapeutics.
Position Overview:We are seeking an exceptional Director of Non-Clinical Research and Development to spearhead our preclinical research endeavors. The ideal candidate will play a pivotal role in driving the optimization and advancement of our LNP platform through strategic planning, experimental design, and team leadership. This position offers an exciting opportunity to build a talented group of scientists, collaborate with key stakeholders, and contribute to the development of transformative delivery mechanisms.
Key Responsibilities:Lead research, designing, planning, and executing preclinical studies to evaluate the efficacy, safety, and pharmacokinetics of LNP-based therapeutic delivery systems.Develop and implement research strategies to optimize LNP formulations and delivery systems, leveraging expertise in protein engineering and DNA/RNA therapeutics.Cultivate strong relationships with external partners, including contract research organizations (CROs) and academic collaborators, to support preclinical studies and ensure timely project execution.Generate high-quality scientific data to support regulatory submissions, including IND filing, and drive product development milestones.Collaborate cross-functionally with colleagues in research, clinical development, regulatory affairs, and manufacturing to integrate non-clinical findings into overall product development strategies.Stay informed of advancements in lipid nanoparticle technology and relevant scientific literature to inform decision-making and maintain competitiveness.Contribute to scientific publications, presentations, and patent applications to communicate research findings and protect intellectual property.Foster a culture of scientific excellence, innovation, and collaboration within the Non-Clinical team and across the organization.Additional Information:Experience with IND applications and regulatory processes for drug development, including interactions with regulatory agencies such as the FDA.Familiarity with protein engineering techniques and their applications in therapeutic development, particularly in the context of lipid nanoparticle-based delivery systems.Leadership experience overseeing non-clinical activities post-IND, including toxicology studies, pharmacology assessments, and IND-enabling studies.Onsite presence required in San Francisco, facilitating collaboration with cross-functional teams and external partners.Direct involvement in coordinating activities with CROs, including technology transfer, QC, and study oversight.Experience working with laboratory facilities such as Baker and NBC for research and development activities.We Offer:Competitive salary in the range of $200,000 to $250,000, commensurate with experience and qualifications.Opportunity for a 20% performance-based bonus, reflecting the company's commitment to rewarding exceptional contributions.Equity participation in the range of 3-5%, providing a stake in the company's success and alignment with long-term growth objectives.
Join us and be part of a dynamic team driving innovation in biotechnology and medicine. Together, we are pioneering new treatments and improving the lives of patients worldwide.
Apply now to make a difference!
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